YAP limits expansion
نویسندگان
چکیده
منابع مشابه
A feed-forward loop between lncARSR and YAP activity promotes expansion of renal tumour-initiating cells
Renal tumour-initiating cells (T-ICs) contribute to tumorigenesis, progression and drug resistance of renal cell carcinoma (RCC). However, the underlying mechanism for the propagation of renal T-ICs remains unclear. Here we show that long non-coding RNA lncARSR is upregulated in primary renal T-ICs and associated with a poor prognosis of clear cell RCCs (ccRCC). Knockdown of lncARSR attenuates ...
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ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2012
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc3436